New Spectrophotometric Methods for the Estimation of Gefitinib in Bulk Drug and Formulations
نویسندگان
چکیده
Two simple, precise and accurate spectrophotometric methods were developed for the estimation of Gefitinib in bulk drug and in pharmaceutical formulations. Method A and B is based on oxidation of followed by coupling of 3metyl-1,2-benzothiazolinone hydrazone (MBTH) with Gefitinib using Ferric chloride and Cerric ammonium nitrate(CAN) and measuring the chromogen at the λmax of 438 and 675 respectively. Both the methods follow beer’s law in the concentration range of 100-700 μg/ml with MBTH and FeCl3 and 50-250 μg/ml with MBTH and CAN. The accuracy of the methods was determined by recovery studies. The methods showed good reproducibility and recovery with relative standard deviation (in %) less than 2. The methods were found to be simple, economical, accurate and reproducible and can be used for routine analysis of Gefitinib in bulk drug and in pharmaceutical formulations.
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